Research Topics

  • Gradient High Performance Liquid Chromatography (RP HPLC)
  • Theoretical basis of retention in new chromatographic techniques like: pH gradient and combined pH/organic modifier gradient
  • Determination of pKa and hydrophobicity/lipophilicity by means of RP HPLC
  • Optimization of HPLC separations
  • Quantitative Structure-Retention Relationships, QSRR
  • Pharmacokinetics and Pharmacodynamics of drugs (PK/PD)
  • Population (nonlinear mixed effect) PK/PD modeling (Nonmem, Monolix, etc.)
  • Clinical data analysis with special emphasis on PK/PD of drugs used in anesthesia, like propofol, midazolam, opioids, etc.
  • Application of multilevel (hierarchical) modeling and Bayesian inference techniques in chromatography and pharmacometrics.